Ru-BDPX-DPEN催化芳香酮的不对称氢化反应

设计合成了一种新型的钌-双膦-手性二胺三元配合物RuC l2(BDPX)[(S,S)-DPEN][BDPX=邻-二(二苯基膦)甲苯,DPEN=1,2-二苯基乙二胺].利用此配合物作催化剂催化了苯乙酮和几种取代苯乙酮的不对称氢化反应;考察了多种因素对苯乙酮不对称氢化反应的转化率和ee值的影响.结果表明,此配合物对苯乙酮进行不对称氢化反应具有良好的催化性能和较高的对映选择性,在优化的条件下,当苯乙酮、配合物的摩尔比为20000?1时,其不对称氢化反应的转化率可达到100%,其ee值可达到59.0%;对取代苯乙酮的不对称氢化反应也具有一定的催化活性和中等的对映选择性.

Ru-BDPX-DPEN a Novel Catalyst for Asymmetric Hydrogenation of Simple Aromatic Ketones

A novel Ruthenium complex RuCl2(BDPX)(S,S-DPEN)(BDPX=1,2-bis(diphenylphosphinomethy1)benzen,S,S-DPEN=S,S-1,2-diphenyl ethylenediamine) was synthesized and it was used as an effective catalyst in the asymmetric hydrogenation of a diverse range of simple aromatic ketones.The enfluence of various factors on the asymmetric hydrogenation of acetophenone was studied.Results revealed that this complex was an effective and highly enantioselective catalyst.The hydrogenation of acetophenone with S/C=20 000 in optimized conditions gave 100% conversion and 59.0% ee.Highly enantionselectivities were achieved in the hydrogenation for other simple aromatic ketones.