Can efficiency of the photosensitizer be predicted by its photostability in solution? |
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Authors: | J. Ferreira P. F. C. Menezes C. H. Sibata R. R. Allison S. Zucoloto O. Castro e Silva Jr V. S. Bagnato |
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Affiliation: | 1. Instituto de Fizica de S?o Carlos-IFSC-University of S?o Paulo (USP), Av. Trabalhador Sancarlense no. 400, Caixa Postal 369, CEP 13560-970, S?o Carlos, SP, Brazil 2. Faculdade de Medicina de Ribeir?o Preto-FMRP-University of S?o Paulo (USP), Ribeir?o Preto, S?o Paulo, Brazil 3. Brody School of Medicine at East Carolina University, Greenville, NC, USA
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Abstract: | We have investigated a possible correlation between the photostability and photodynamic efficacy for different photosensitizers; hematoporphyrin derivatives and chlorines. To perform such analysis, we combined the depth of necrosis (d nec) measurement, expressed by the light threshold dose and a photodegradation parameter, measured from investigation of photosensitizer degradation in solution. The d nec analysis allows us to determine the light threshold dose and compare its value with the existent results in the literature. The use of simple models to understand basic features of Photodynamic Therapy (PDT) may contribute to the solid establishment of dosimetry in PDT, enhancing its use in the clinical management of cancers and others lesions. Using hematoporphyrin derivatives and chlorines photosensitizers we investigated their properties related to the photodegradation in solution and the light threshold dose (D th) in rat livers. |
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