Synthesis and biological evaluation of novel acenaphthene derivatives as potential antitumor agents |
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Authors: | Xie Yong-Mei Deng Yi Dai Xiao-Yun Liu Jie Ouyang Liang Wei Yu-Quan Zhao Ying-Lan |
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Institution: | State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China. |
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Abstract: | Twelve novel acenaphthene derivatives have been synthesized. The structures of all compounds were confirmed by 1H-NMR, MS and elemental analysis. Their antitumor activities were evaluated in six human solid tumor cell lines, namely non-small cell lung cancer (H460), human colon adenocarcinoma (SW480), human breast cancer cell (MDA-MB-468 and SKRB-3), human melanoma cell (A375) and human pancreatic cancer (BxPC-3). Among them, compound 3c shows the best antitumor activity against SKRB-3 cell line, as high as the positive control adriamycin. |
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