Plastic membrane electrodes for the potentiometric determination of codeine in pharmaceutical preparations |
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Authors: | Eman M Elnemma M A Hamada |
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Institution: | (1) Department of Chemistry, Faculty of Science, Qatar University, P.O.Box 2713, Doha, Qatar |
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Abstract: | Four PVC membrane electrode systems responsive to codeinium cation are described. These electrodes are based on the use of the ion-association complexes of the codeinium cation with tetraphenylborate and reineckate counter-anions as ion-exchange sites in a PVC matrix plasticized with dioctylphthalate and dibutylsebacate. The performance characteristics of these electrodes reveal fast, stable and near-Nernstian responses for codeine down to concentrations of 3.5–7.0 × 10–5
M. Over the pH range 2.5–7, the electrodes are satisfactory for manual and flow injection determination of codeine in various pharmaceutical preparations. There is negligible interference from a number of inorganic and organic cations and some common drug excipients. In the direct determination of 30 g/ml -1.0 mg/ml codeine, the average recovery is 100.6% and the mean standard deviation is ± 0.8%. The results compare favorably with those obtained by the British Pharmacopoeia method. |
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Keywords: | potentiometry codeine PVC membrane electrode codeine reineckate tetraphenylborate pharmaceutical analysis drug ion-selective electrode |
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