Ring transformations of 1,3-benzothiazine derivatives II conversion of 6α-aryl-7α-chloro-2,3(2′,3′-dialkqxybenzo)-1-thiaoctems3 into 2-carbomethoxy-3-aryl-7,8-dialkoxy-4.5-dihydro-1,4-benzothiazepines期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Ring transformations of 1,3-benzothiazine derivatives II conversion of 6α-aryl-7α-chloro-2,3(2′,3′-dialkqxybenzo)-1-thiaoctems3 into 2-carbomethoxy-3-aryl-7,8-dialkoxy-4.5-dihydro-1,4-benzothiazepines

Authors:	Lajos Fodor János Szabó Erzsébet Szúcs Gábor Bernáth Pál Sohár József Tamás

Institution:	Central Laboratory, County Hospital, H-5701 Gyula POB 46, Hungary;Institute of Pharmaceuttical Chemistry, University Medical School, H-6701 Szeged POB 121, Hungary;Spectroscopic Department, EGYT Pharmacochemical Works, H-1475 Budapest, POB 100, Hungary;Central Research Institute of Chemistry, Hungarian Academy of Sciences, H-1525 Budapest POB 17, Hungary

Abstract:	6,7-Dialkoxy-2-aryl-4 $H$ 1-1,3-benzothiazines (1a?) react with chloroacetyl chlorlde to give condensed β-lactam derivatives (2a?). Basic treatment of 2a? in methanol led to the corresponding 1,4-banzothiazepine derivativee (3a?) $via$ ring expansion. The structures of the products were determined by IR, NMR and MS studies

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