Seven new hindered isomeric rhodopsins: A reexamination of the stereospecificity of the binding site of bovine opsin |
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| Authors: | Hiroyuki Matsumoto Aravinda Kini Alfred E. Asato Marlene Denny Allen Kropf Willem J. DeGrip |
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| Affiliation: | Department of Biochemistry, University of Nijmegen, Geert Grooteplein noord 21, Postbus 9101-6500 HB, Nijmegen Netherlands;Department of Chemistry, Amherst College, Amherst MA 01002, U.S.A.;Department of Biochemistry, University of Nijmegen, Geert Grooteplein noord 21, Postbus 9101-6500 HB, Nijmegen Netherlands |
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| Abstract: | Results of interaction of seven new geometric isomers of retinal (7-cis, 7,9-dicis; 7,11-dicis, 7,13-dicis; 9,11-dicis 7,9,11-tricis 7,9,13-tricis) with bovine opsin are reported. All of them form pigments with absorption maxima varying between 450 and 480 nm. The rates of pigment formation were generally considerably lower than those of 11-cis-retinal and the yields were less than quantitative. Implications of these results for the stereospecificity of the binding site of opsin are discussed. |
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