Convergent and stereoselective synthesis of vitamin D3 via 3,5-cyclovitamins D3 |
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Authors: | Hideo Nemoto Hiroshi Kurobe Masataka Ihara Keiichiro Fukumoto Tetsuji Kametani |
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Institution: | 1. Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980, Japan;2. Institute of Medicinal Chemistry, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142, Japan |
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Abstract: | A convergent and stereoselective synthesis of vitamin D3 was achieved via 3,5-cyclovitamins D3 (20) which were prepared from the chiral aldehyde (2) and the vinyl bromide (12) derived from Grundmann's ketone. |
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