A new class of condensing reagents for rapid internucleotide bond formation in the phosphotriester approach and preparation of n<sup>3</sup>-benzoylthymidine as a key intermediate in oligodeoxyribonucleotide synthesis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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A new class of condensing reagents for rapid internucleotide bond formation in the phosphotriester approach and preparation of n³-benzoylthymidine as a key intermediate in oligodeoxyribonucleotide synthesis

Authors:	Jun-ichi Matsuzaki Hitoshi Hotoda Mitsuo Sekine Tujiaki Hata

Institution:	Department of Life Chemistry, Tokyo Institute of Technology Nagatsuta, Midoriku, Yokohama 227,Japan

Abstract:	Rapid internucleotide bond formation in the phosphotriester approach has been achieved in high yield by use of bis(2,4,6-trihalophenyl) phosphorochloridates (TCP and TBP) as new condensing reagents and the benzoyl group as the N³-imide protecting group of thymidine.

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