Agelasine-E and -F,novel monocyclic diterpenoids with 9-methyladeninium unit possessing inhibitory effects on Na,K-ATPase isolated from the Okinawan sea sponge Hoshino |
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Authors: | Houming Wu,Hideshi Nakamura,Jun ichi Kobayashi,Yasushi Ohizumi,Yoshimasa Hirata |
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Affiliation: | Mitsubishi-Kasei Institute of Life Sciences, 11 Minamiooya, Machida-shi, Tokyo 194, Japan;Faculty of Pharmacy, Meijo University, Tempaku, Nagoya 468, Japan |
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Abstract: | Agelasine-E and -F, novel terpenoids with a 9-methyladeninium unit have been isolated from the orange colored sea sponge Hoshino as Na,k-ATPase inhibitors and their structures and absolute configurations have been determined on the basis of spectral data and chemical conversions. |
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