Preparation and characterization of two new water-soluble endohedral metallofullerenes as magnetic resonance imaging contrast agents |
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Authors: | Zhang Er-Yun Shu Chun-Ying Feng Lai Wang Chun-Ru |
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Institution: | Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China. |
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Abstract: | Two new water-soluble Gd-containing endohedral metallofullerenes ScxGd3-xN@C80OmOHn (x = 1, 2; m approximately 12; n approximately 26)] were synthesized in a simple one-step reaction and characterized by Fourier transform (FT)-IR as well as X-ray photoelectron spectroscopy (XPS). Their observed longitudinal relaxivities (R1) for water protons are 20.7 and 17.6 mM(-1) s(-1), respectively, which are significantly higher than that of the commercial magnetic resonance imaging (MRI) contrast agent (Gd-DTPA, 3.2 mM(-1) s(-1)). These results indicate these trimetallic nitride endohedral fullerenols are potential next-generation high-efficiency MRI contrast agents. |
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