Organocatalytic mediated green approach: A versatile new L-valine promoted synthesis of diverse and densely functionalized 2-amino-3-cyano-4H-pyrans |
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Authors: | Jyoti Tiwari Swastika Singh Mohammad Saquib Fatima Tufail Amit Kumar Sharma Shailesh Singh |
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Affiliation: | 1. Environmentally Benign Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad, India;2. Department of Chemistry, S. S. Khanna Girls Degree College, Allahabad, India |
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Abstract: | The discovery of a new L-valine promoted facile and versatile green synthesis of diversified 2-amino-3-cyano-4H-pyrans using a one pot multicomponent-tandem reaction of aromatic aldehydes, malononitrile, and diverse electron-rich enolizable carbonyl compounds is described. To the best of our knowledge this is the first report on the use of native L-valine as a catalyst in organic synthesis. Environmental friendly, mild reaction conditions, use of easily available inexpensive starting materials, short reaction time, excellent yields, high atom economy, and recyclability of organocatalyst are the major advantages of the disclosed protocol. |
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Keywords: | 2-Amino-3-cyano-4H-pyrans smallcaps smallerCapital" >L-valine green synthesis multicomponent water |
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