Convenient synthesis of 2-(methylsulfonyl)pyrimidine derivatives |
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| Authors: | Tong-Hui Huang Shan-Shan Zhou Xin Wu Lin An |
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| Affiliation: | Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical University, Xuzhou, China |
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| Abstract: | An efficient and convenient approach for the preparation of functionalized 2-(methylsulfonyl)pyrimidine derivatives has been developed through cyclic condensation of malonate derivatives with S-methylisothiouronium sulfate followed by derivation and oxidation in water–acetone mixture using oxone as the oxidant. This synthetic strategy provides an efficient and environmentally friendly approach for easy access to 2-(methylsulfonyl)pyrimidine derivatives with considerable yields. |
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| Keywords: | 2-(Methylsulfonyl)pyrimidine 2-(methylthio)pyrimidine cyclization oxidation |
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