Facile synthesis of TEG-substituted 4-(N-methyl-N-Boc-amino)styrylpyridine and PET imaging agent [F]florbetapir ([F]AV-45) |
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| Authors: | Tuo Yao |
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| Institution: | Department of Chemistry, School of Science, Beijing Jiaotong University, Beijing, China |
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| Abstract: | Triethylene glycol-substituted 4-(N-methyl-N-Boc-amino)styrylpyridine which can serve as key precursor for many monodentate and multidentate imaging agents for Aβ plaques in human brain has been readily synthesized with cost-effective starting materials. The important non-radioactive monodentate positron emission tomography agent F]florbetapir (F]AV-45) has also been prepared by our new method. |
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| Keywords: | [F]AV-45 [F]florbetapir β plaques" target="_blank">Aβ plaques PET imaging agent |
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