Metal-free synthesis of 2-aminothiadiazoles via TBHP-Mediated oxidative C-S bond formation |
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Authors: | Navnath T Hatvate Shrikant M Ghodse |
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Institution: | Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai, India |
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Abstract: | An efficient one-pot synthesis of 2-amino-1,3,4-thiadiazoles from easily available aldehydes and thiosemicarbazide using TBHP as an oxidant has been described. Notably, these reactions were carried out at room temperature using ethanol as solvent. This is the first example for one-pot synthesis of 2-amino-1,3,4-thiadiazole derivatives from aldehydes. This new synthetic methodology provides a simple procedure utilizing a safer oxidizing system that affords the target products in mild reaction condition with satisfactory yields and wide substrate scope. |
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Keywords: | 1 3 4-Thiadiazole aldehydes c-s bond formation metal free TBHP |
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