Cu(I)-phosphine complex: An efficient catalyst for synthesis of 3-indole derivatives through one-pot MCR under mild conditions |
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Authors: | Avvari N Prasad Felipe C Braga Rosângela da S Lopes Gleison A Casagrande Dênis P de Lima |
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Institution: | Institute of Chemistry of Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil |
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Abstract: | An efficient copper (I) halotriphenylphosphine catalyzed one-pot multicomponent reaction (MCR) of 3-substituted indole derivatives has been developed using a variety of aldehydes (aromatic, aliphatic, and heteroaromatic), indole, and active methylene substrates such as malononitrile and ethyl 2-cyano acetate. This reaction proceeds smoothly and obtained good to excellent yields (68–93%) using water as green solvent under ambient conditions. The obtained products were confirmed by 1H, 13C NMR, and mass spectroscopy techniques. The one-pot MCR occurs through formation of Knoevenagel adducts then followed by Michael addition of indole. |
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Keywords: | 3-Substituted indoles Cu-catalysis multicomponent reaction water Yonemitsu condensation |
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