Eco-friendly synthesis of pyrimidines and its derivatives: A review on broad spectrum bioactive moiety with huge therapeutic profile

Among all heterocyclic compounds, pyrimidine is of prime interest, exhibit broad spectrum of biological activities, because of its occurrence in deoxyribonucleic acid bases. The bioactive moiety pyrimidine has a voluminous therapeutic profile as it is a vital component of a series of natural composites and chemotherapeutic drugs. Since from last 50–60 years, this motif has been used commendably against bacterial, tuberculosis viral, malarial, fungal, and cancerous contagions. Recently, numerous pyrimidine derivatives were synthesized and discussed here, fused with other heterocyclic moieties, pyrazole, coumarine, triazole, alkenyloxindole, hydrazine and others, were also investigated for their bioactivities. Amid all recently reported compounds, several exhibit potentials against breast cancer cell lines. Intensive research has been performed and is going ahead with distinctive emphasis on antineoplastic potential of pyrimidine. These widespread medicinal attributes impulse scientists to synthesize more and more biologically active pyrimidine composites by following simple and eco-friendly routes.