Efficient synthesis of spirooxindole-pyrrolizidines and dispirooxindole-piperazines |
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| Authors: | Keshri Nath Tiwari Taur Prakash Pandurang Suyash Pant P Sreelekha |
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| Institution: | Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, Uttar Pradesh, India |
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| Abstract: | A simple and efficient approach for the construction of spirooxindole-pyrrolizidines and dispirooxindole-piperazines by cycloaddition reaction of azomethine ylide generated by isatin and proline has been demonstrated successfully. The formation of two different types of frameworks by two different modes of cycloaddition is explored. The developed protocol highlights simple reaction conditions, easy workup processes, and very good yields of products. |
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| Keywords: | Azomethine ylide cycloaddition isatin piperazine spirooxindole |
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