Synthesis and biological evaluation of some novel thiadiazole-benzofuran hybrids as potential antitumor agents |
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| Authors: | Abdou O. Abdelhamid Nadia A. Abdelrehem Ahmed M. Shalaby Sahar M. Kandeel |
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| Affiliation: | 1. Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt;2. Department of Peptide Chemistry, National Research Center, Dokki, Cairo, Egypt;3. Department of Natural Compounds, National Research Center, Dokki, Cairo, Egypt |
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| Abstract: | Two series of novel 1,3,4-thiadiazole-benzofuran and 1,3,4-thiadiazole-furochromene derivatives were synthesized through heterocyclization of alkyl 2-(1-(6-hydroxy-4,7-dimethoxybenzofuran-5-yl)ethylidene)hydrazine-1-carbodithioate 3a–f and 2-(1-(5-methoxy-8-methyl-2,6-dioxo-2,6-dihydropyrano[3,2-g]chromen-3-yl)ethylidene)hydrazinecarbothioamide 9a,b with various hydrazonoyl halides, respectively. The structure of the newly synthesized products was elucidated through elemental analysis, spectral data and alternative routes whenever possible. Ten new compounds were evaluated for their anticancer activity against the human breast carcinoma (MCF-7) cell lines in comparison with reference doxorubicin using MTT assay. The results showed that some new compounds have promising anticancer activity. |
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| Keywords: | 1,3,4-Thiadiazoles antitumor activity benzofuran hydrazonoyl halides khellinone |
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