Efficient synthesis of tertiary amine by direct N-alkylation of secondary amine with carboxylic acid using Ni (0) encat catalyst |
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Authors: | Syed Aziz Imam Quadri Tonmoy C. Das Shivaji Jadhav |
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Affiliation: | Department of Chemistry, Dr. Rafiq Zakaria College for Women, Aurangabad, India |
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Abstract: | In this article, direct N-alkylation of secondary amines with carboxylic acid is described. Readily available diversified carboxylic acid has been explored on variant secondary amines using encapsulated Nickel as catalyst and inexpensive sodium borohydride as the hydride source. High yields, mild reaction conditions, tolerance to sensitive functional group and facile operational procedure are the significance of the present methodology. |
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Keywords: | Encapsulated Ni N-alkylation sodium borohydride tertiary amine |
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