Photophysical properties of pyridyloxy phthalocyanine encapsulated in nanoparticles |
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| Authors: | Kuizhi Chen Di Zeng Ying Huang Yawen Chen Yide Huang Shusen Xie |
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| Affiliation: | 1. Fujian Provincial Key Laboratory of Polymer Materials, Fujian Provincial Key Laboratory of Advanced Oriented Chemical Engineering, Fujian Normal University, Fuzhou, China;2. Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, College of Life Sciences, Fujian Normal University, Fuzhou, China;3. Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou, China |
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| Abstract: | Two aluminum chloride phthalocyanines with pyridyloxy substitution at α/β positions were synthesized. Their structures were characterized by infrared spectroscopy, proton nuclear magnetic resonance as well as elemental analysis. Tetra-α(β)-(2-pyridyloxy) aluminum chloride phthalocyanines were encapsulated into a diblock copolymer methoxy-poly(ethylene glycol)-block-poly(L-lysine) through a cosolvent method. The morphologies and photophysical properties of phthalocyanines encapsulated in nanoparticles were studied by transmission electron microscope, ultraviolet-visible, and fluorescence spectroscopic methods. The photophysical properties of phthalocyanines encapsulated into nanoparticles exhibited substitution positions dependence. The phthalocyanines with substitution at α positions were found to be an excellent candidate for use as photosensitizers for treatment of cancer by photodynamic therapy. |
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| Keywords: | Aluminum chloride phthalocyanine photophyscial properties poly(ethylene glycol)-block-poly(L-lysine) polymeric nanoparticles pyridyloxy |
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