Chemoenzymatic synthesis of (R)- and (S)-1-heteroarylethanols |
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Authors: | Monica Ioana Toa Paula Veronica Podea Csaba Paizs Florin Dan Irimie |
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Institution: | aDepartment of Biochemistry and Biochemical Engineering, Babeş-Bolyai University, Arany János 11, 400028 Cluj-Napoca, Romania |
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Abstract: | A chemoenzymatic methodology for the synthesis of highly enantiomerically enriched (S)- and (R)-1-heteroarylethanols by enantioselective bioreduction with baker’s yeast of the corresponding 1-heteroarylethanones followed by three racemization free chemical steps including a Mitsunobu reaction was developed. |
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