A chiral molecular recognition approach to the formation of optically active quaternary centres in aza-Henry reactions |
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Authors: | Knudsen Kristian Rahbek Jorgensen Karl Anker |
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Institution: | Danish National Research Foundation: Center for Catalysis, Department of Chemistry, Aarhus University, Denmark. |
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Abstract: | An approach to asymmetric catalysis based on chiral molecular recognition by the combination of chiral Lewis acids and chiral organocatalysis for the formation of optically active quarternary centers in the aza-Henry reaction is presented; this procedure leads to products with up to 98% ee and a diastereomeric ratio of 14 : 1 in excellent yields with catalyst loadings of 5 mol%. |
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