High stereoselectivity in chelation-controlled intermolecular Heck reactions with aryl chlorides, vinyl chlorides and vinyl triflates |
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Authors: | Datta Gopal K Larhed Mats |
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Affiliation: | Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, BMC, Uppsala, Box 574, SE-751 23, Sweden. |
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Abstract: | Highly stereoselective chelation-controlled Pd(0)-catalyzed beta-arylations and beta-vinylations of a five-membered chiral, pyrrolidine-based vinyl ether were achieved using aryl- and vinyl chlorides as substrates, yielding quaternary 2-aryl/vinyl-2-methyl cyclopentanones in 89-96% ee under neutral reaction conditions. |
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