Determination of azelastine and desmethylazelastine in human plasma by high-performance liquid chromatography |
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| Authors: | J Pivonka F H Segelman C A Hartman W E Segl N Kucharczyk R D Sofia |
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| Affiliation: | Wallace Laboratories, Division of Carter-Wallace, Inc., Cranbury, NJ 08512. |
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| Abstract: | A manual-injection liquid chromatographic method using fluorescence detection permitted determination of a new antiasthmatic drug, azelastine, and its desmethyl metabolite extracted from human plasma. Reliable quantitation was achieved to at least 0.3 ng/ml for each analyte. No interference was seen in co-chromatography of sixteen other substances, which were potential co-medications (or their metabolites) as used in standard asthma or allergy treatment. |
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