An ultrasensitive colorimeter assay strategy for p53 mutation assisted by nicking endonuclease signal amplification |
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| Authors: | Lin Zhenyu Yang Weiqiang Zhang Guiyun Liu Qida Qiu Bin Cai Zongwei Chen Guonan |
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| Institution: | Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fuzhou University, Fuzhou, Fujian, 350002, China. zylin@fzu.edu.cn |
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| Abstract: | A novel catalytic colorimetric assay assisted by nicking endonuclease signal amplification (NESA) was developed. With the signal amplification, the detection limit of the p53 target gene can be as low as 1 pM, which is nearly 5 orders of magnitude lower than that of other previously reported colorimetric DNA detection strategies based on catalytic DNAzyme. |
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