Extracellular ascorbate modulates glutamate dynamics: role of behavioral activation |
| |
| Authors: | Michael I Sandstrom George V Rebec |
| |
| Institution: | (1) Psychology Department, Central Michigan University, Mount Pleasant, MI, USA;(2) Department of Psychological & Brain Sciences, Indiana University Bloomington, Bloomington, IN, USA |
| |
| Abstract: | Background A physiological increase in extracellular ascorbate (AA), an antioxidant vitamin found throughout the striatum, elevates extracellular
glutamate (GLU). To determine the role of behavioral arousal in this interaction, microdialysis was used to measure striatal
GLU efflux in rats tested in either a lights-off or lights-on condition while reverse dialysis either maintained the concentration
of AA at 250 μM or increased it to 1000 μM to approximate endogenous changes. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
