Highly diastereo- and enantioselective tandem reaction toward functionalized pyrrolidines with multiple stereocenters |
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| Authors: | Guo Shengmei Xie Yinjun Hu Xinquan Huang Hanmin |
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| Affiliation: | State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, PR China. |
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| Abstract: | An efficient asymmetric tandem dual Michael reaction that constructs three contiguous stereocenters in acyclic open-chain systems with very high enantioselectivity and diastereoselectivity has been developed. This protocol provides a reliable and rapid approach for synthesis of chiral pyrrolidines with multiple stereocenters. |
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