Synthesis of an NDPK phosphocarrier domain peptide containing a novel triazolylalanine analogue of phosphohistidine using click chemistry |
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| Authors: | Yang Sung Hyun Lee Dong Jun Brimble Margaret A |
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| Institution: | School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland, New Zealand. |
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| Abstract: | Click phosphorylation of a propargylated unprotected peptide and phosphoryl azide using chaotrope-assisted Cu(I)-catalyzed 1,3-dipolar cycloaddition enabled a high-yielding and rapid synthesis of a nucleoside diphosphate kinase (NDPK) phosphocarrier domain. The synthesis showcases a valuable synthetic platform for the synthesis of biologically relevant phosphopeptide analogues. |
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