Total synthesis and stereochemical revision of acortatarins A and B |
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| Authors: | Sudhakar Gangarajula Kadam Vilas D Bayya Shruthi Pranitha Gavinolla Jagadeesh Bharatam |
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| Institution: | Organic Chemistry Division-II, CSIR-Indian Institute of Chemical Technology, Hyderabad-500 607, India. gsudhakar@iict.res.in |
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| Abstract: | A first total synthesis of acortatarins A, B, and an enantiomer of the proposed structure of acortatarin B is described by using readily available d-sugars. This convergent total synthesis revealed the revision of the absolute configuration of acortatarin A and structural revision of acortatarin B. The key steps involved are regioselective epoxide opening with deprotonated 2,5-disubstituted pyrrole and spiroketalization. |
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