Efficient synthesis of benzofuranones: N-heterocyclic carbene (NHC)/base-catalyzed hydroacylation-Stetter-rearrangement cascade |
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| Authors: | Padmanaban Mohan Biju Akkattu T Glorius Frank |
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| Affiliation: | Westf?lische Wilhelms-Universit?t, NRW Graduate School of Chemistry, Organisch-Chemisches Institut, Corrensstrasse 40, 48149 Münster, Germany. |
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| Abstract: | A N-heterocyclic carbene/base-catalyzed cascade reaction leading to the formation of functionalized benzofuranones is reported. The reaction proceeds via an intramolecular hydroacylation of unactivated alkynes followed by an intermolecular Stetter reaction and a base-catalyzed chromanone to benzofuranone rearrangement. |
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