Spectroscopic and biological properties of platinum complexes derived from 2-pyridyl Schiff bases |
| |
| Institution: | 1. Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203 Jeddah 21589, Saudi Arabia;2. Department of Chemistry, College of Science and Arts, King Abdulaziz University, P.O. Box 344 Rabigh 21911, Saudi Arabia;3. Department of Chemistry, Faculty of Science, Port Said University, Port Said 42521, Egypt;4. Department of Biology, College of Science and Arts, King Abdulaziz University, P.O. Box 344 Rabigh 21911, Saudi Arabia |
| |
| Abstract: | The reactions of a range of aromatic primary amines with pyridine-2-carboxaldehyde were reported, highlighting the effect of the substituents of the amine on the outcomes of the Schiff base reactions. The variant products of the Schiff base reactions were reacted with cis-PtCl2(DMSO)2], generating platinum(II) complexes with PtCl2(N^N) general formula. The ligands and platinum(II) complexes were identified and characterized by IR and NMR spectroscopic methods. Single crystal XRD offered structural confirmation for three of the organic compounds and two platinum complexes. The spectral, antimicrobial, DNA-binding and molecular docking of the platinum complexes were studied, highlighting the effect of the different functional group in the Schiff base ligands on their properties. In general, introducing the electron-withdrawing group nitro or acetyl in the 2-pyridyl Schiff base ligands, results in a red-shift in the absorption maxima of the platinum complex. In addition, the enhancement in the antimicrobial activities and the increase in the ct-DNA-binding affinity were also observed when the nitro or acetyl functional group is introduced to the Schiff base ligand in the platinum(II) complex. |
| |
| Keywords: | Pyridyl Schiff base Platinum(II) complexes Biological activity DNA binding Molecular docking |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
