Synthesis of oxazoles through Pd-catalyzed cycloisomerization-allylation of N-propargylamides with allyl carbonates |
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| Authors: | Akio Saito |
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| Institution: | Laboratory of Organic Reaction Chemistry, Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan |
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| Abstract: | In the presence of Pd2(dba)3-Cy3P catalyst, IPr·HCl salt IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene], and Cs2CO3, N-propargylamides react with allyl carbonates to give 2,5-disubstituted oxazoles having homoallyl groups through the tandem cycloisomerization-allylation. |
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