Electrosynthesis of fluorinated indole derivatives |
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| Authors: | Bin Yin |
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| Institution: | Department of Electronic Chemistry, Tokyo Institute of Technology, Nagatsuta, Midori-ku, Yokohama 226-8502, Japan |
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| Abstract: | Anodic fluorination of various N-acetyl-3-substituted indole derivatives was successfully carried out in Et4NF-4HF/MeCN to provide the corresponding trans-2,3-difluoro-2,3-dihydroindoles exclusively or selectively. Treatment of difluorinated products with a base provided monofluoroindole derivatives or monofluoroindoline derivative depending on the substituents at the 3-position. |
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| Keywords: | Electrolytic fluorination Fluoroindole derivatives Fluoroindoline |
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