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Synthesis of 3-methoxy-quinoxalin-2-ones from methyl trimethoxyacetate and phenylenediamines |
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| Authors: | Jennifer D Venable David E Kindrachuk James P Edwards |
| Institution: | a Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA b TransForm Pharmaceuticals, Inc., 29 Hartwell Avenue, Lexington, MA, USA |
| Abstract: | Treatment of phenylenediamines with methyl trimethoxyacetate led to the formation of 3-methoxy-quinoxalin-2-ones with the assistance of lanthanide-based Lewis acids. |
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