A double Mannich approach to the synthesis of substituted piperidones—application to the synthesis of substituted E-ring analogues of methyllycaconitine |
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Authors: | Yinman Chan |
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Institution: | Department of Chemistry, University of Auckland, 23 Symonds St, Auckland, New Zealand |
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Abstract: | The double Mannich reaction of acyclic α,γ-substituted β-keto esters and bis(aminol) ethers gives substituted 3,5-substituted-4-piperidones with high levels of diastereoselectivity. These piperdiones can be easily transformed into substituted E-ring analogues of the delphinium alkaloid methyllycacotine. |
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Keywords: | Mannich reaction 4-Piperidones Multicomponent reaction Methyllycacontine |
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