A convenient one-pot synthesis of trisubstituted 1,3,5-triazines through intermediary amidinothioureas |
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| Authors: | Jitendra C. Kaila |
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| Affiliation: | Department of Medicinal Chemistry, B.V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Thaltej-Gandhinagar Highway, Thaltej, Ahmedabad 380 054, Gujarat, India |
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| Abstract: | A thiophile-promoted one-pot synthesis of trisubstituted 1,3,5-triazines starting from isothiocyanates, N,N-diethylamidines, and carbamidines has been studied. The reaction proceeds through the formation of intermediary amidinothioureas, which react with carbamidines in the presence of mercury(II) chloride to generate the desired 1,3,5-triazines in good to moderate yields (40-70%). |
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| Keywords: | Thiophile 1,3,5-Triazines Amidinothioureas Carbamidines |
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