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Facile p-toluenesulfonic acid-promoted para-selective monobromination and chlorination of phenol and analogues |
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| Authors: | Pakorn Bovonsombat Rameez Ali Chiraphorn Khan Juthamard Leykajarakul Kawin Pla-on Suraj Aphimanchindakul Natchapon Pungcharoenpong Nisit Timsuea Anchalee Arunrat Napat Punpongjareorn |
| Institution: | Mahidol University International College, Mahidol University, Salaya campus, Nakorn Pathom 73170, Thailand |
| Abstract: | para-Regioselective bromination of phenol and analogues, promoted by p-toluenesulfonic acid, is achieved in high to excellent yields at room temperature with N-bromosuccinimide. Chlorination with N-chlorosuccinimide and catalysed by p-toluenesulfonic acid also gives para-chlorinated phenol analogues in good yields at room temperature. |
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