Synthesis of tetrasubstituted pyrazines and pyrazine N-oxides |
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| Authors: | Jae Uk Jeong Xiaoyang Dong Attiq Rahman Robert W Marquis |
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| Institution: | Medicinal Chemistry, Immuno-Inflammation CEDD, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, United States |
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| Abstract: | An efficient synthesis of tetrasubstituted unsymmetrical pyrazines and their related pyrazine N-oxides has been developed from commercially available 2-chloro-3-methylpyrazine. The procedure and scope of these synthesis routes are described. |
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