Synthesis of epoxy and aziridino malonyl peptidomimetics |
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Authors: | Stefania Fioravanti Federico Ramadori |
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Affiliation: | Dipartimento di Chimica, Università degli Studi di Roma ‘La Sapienza’, P.le Aldo Moro 5, I-00185 Roma, Italy |
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Abstract: | Short malonyl dehydro peptides have been epoxidized using H2O2/Na2WO4 dihydrate. The obtained diastereomeric epoxides were separated by HPLC and successfully tested in the ring opening reaction with N-Boc l-cysteine methyl ester, to indicate their electrophilic behavior. Moreover, by a simple two-step reaction, the epoxy malonyl peptides can be converted into the corresponding aziridino malonyl peptides. |
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Keywords: | Epoxides Aziridines Sodium tungstate Retro-peptides |
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