Chemoselective addition of in situ prepared lithium alkynyl borates to aldehydes: a practical and transition metal free approach toward the synthesis of propargylic alcohols |
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| Authors: | Irene Notar Francesco,Antoine Renier,Franç oise Colobert |
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| Affiliation: | a Laboratoire de stéréochimie, UMR CNRS 7509, Université de Strasbourg (E.C.P.M.), 25 Rue Becquerel, 67087 Strasbourg Cedex 2, France
b Novalix-Pharma, Boulevard Sébastien Brant, BP 30170, F-67405, Illkirch Cedex, France |
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| Abstract: | A convenient synthesis of functionalized propargylic alcohols arising from the 1,2-addition of lithium alkynyl-trimethyl borate onto aldehydes under transition metal free mild conditions is reported. The reaction tolerates a wide range of functional groups, is highly chemoselective and the propargylic alcohols are isolated in good to excellent yields. |
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| Keywords: | Lithium alkynyl borate Aldehyde Propargylic alcohol |
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