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Formal synthesis of semiaquilegin A |
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| Authors: | Jing Li Qingjiang Li Yanxing Jia Pengfei Tu |
| Affiliation: | a State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China b Institute of Organic Chemistry, Jiangxi Science & Technology Normal University, Nanchang 330013, China |
| Abstract: | A formal synthesis of semiaquilegin A is achieved starting from readily available oridonin in 19 linear steps. The absolute configuration of the natural product has been established. A variety of useful analogues were prepared through this synthetic route. |
| Keywords: | Semiaquilegin A Oridonin Barton deoxygenation Formal synthesis |
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