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An efficient synthesis of varenicline |
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| Authors: | Srinivas Pasikanti D Srinivasa Reddy PK Dubey Parthasarathi Das |
| Institution: | a Discovery Research, Dr. Reddy’s Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500 049, AP, India b Department of Chemistry, JNTU College of Engineering, Kukatpally, Hyderabad 500 085, AP, India |
| Abstract: | Synthesis of varenicline the antismoking drug has been achieved in six steps with 10% overall yield. A Diels-Alder reaction, oxidative cleavage of an olefin and reductive amination remain as key steps in the synthesis |
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