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Water works: an efficient palladium-catalyzed cross-coupling reaction between boronic acids and bromoacetate with aminophosphine ligand
Authors:Zhi-Yong Peng  Jiang Cheng  Zhaoguo Zhang
Affiliation:a School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
b College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325027, China
c State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
Abstract:Water greatly restrained the formation of self-coupling of boronic acids in a palladium-catalyzed cross-coupling reaction between boronic acids and ethyl bromoacetate with an aminophosphine ligand; good to excellent yields of cross-coupling product were obtained.
Keywords:Aminophosphine   Boronic acids   Ethyl bromoacetate   Palladium-catalyzed   Water
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