A facile method for synthesis of polysubstituted naphthalene derivatives through pyrrolidine catalyzed domino reaction |
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Authors: | Shi-Guang Li |
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Affiliation: | State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China |
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Abstract: | A novel synthetic method for polysubstituted naphthalene derivatives via a pyrrolidine-mediated cascade Michael/Henry reaction was developed, in which easily prepared 2-(2-oxoethyl)benzaldehydes and nitroalkenes were employed as the starting materials. The reaction consists of four consecutive reactions that include a cascade Michael/Henry reaction, a dehydration reaction, and an aromatization reaction in one pot to afford synthetically important naphthalene derivatives with moderate yields. |
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Keywords: | Organocatalysis Naphthalenes Nitroalkenes Michael/Henry reaction |
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