Efficient synthesis of fluorobenzyloxoimidazolidinone derivatives: precursors for the radiosynthesis of [F]fluorophenylamino acids |
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| Authors: | Johnny Castillo Meleá n,Heinz H. Coenen |
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| Affiliation: | Forschungszentrum Jülich GmbH, Institut für Neurowissenschaften und Medizin, INM-5: Nuklearchemie, D-52425 Jülich, Germany |
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| Abstract: | This paper describes an efficient synthesis of fluorobenzyloxoimidazolidinone derivatives. The title compounds 1a, 1b and 1c could be prepared with high diasteromeric purity (>99%) and overall yields of 19%, 48% and 41% in a ten or six-step synthetic procedure, respectively. These compounds are used as precursors for isotopic 18F-labelling. |
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| Keywords: | Amino acid Oxoimidazolidinone Fluorine-18 18[F]Fluorophenylamino acid Radiopharmaceutical |
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