|
|||||
|
|
DMAP-catalyzed synthesis of 2-oxazolidinones from corresponding halohydrins using KOCN/DMF |
|
| Authors: | K Chinnam Naidu G Ravi Babu L Gangaiah G Madhusudhan |
| Institution: | a Inogent Laboratories Private Limited, A GVK BIO Company, 28A, IDA, Nacharam, Hyderabad 500 076, India b Department of Chemistry, College of Engineering, J.N.T. University, Kukatpally, Hyderabad 500 072, India |
| Abstract: | We report facile and simple synthesis of a variety of 2-oxazolidinones from the corresponding halohydrins by reaction with KOCN in DMF catalyzed by DMAP. DMAP and temperature play key roles in enriching the yield of 2-oxazolidinones. A few examples in this Letter are applicable to pharmaceutically important processes. |
| Keywords: | Linezolid Halohydrin DMAP KOCN 2-Oxazolidinone |
| 本文献已被 ScienceDirect 等数据库收录！ | |