a Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India b Université de Rennes 1, Laboratoire CPM, CNRS UMR 6510, Avenue du Général Leclerc, 35042 Rennes Cedex, France
Abstract:
Aldehyde, homoallylic amine and arene undergo smooth cyclization in the presence of BF3·OEt2 to afford 4-arylpiperidines in good yields and with high trans-selectivity. This is the first report on the preparation of 4-arylpiperidines via aza-Prins-Friedel-Crafts reaction.