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A novel aza-Prins-Friedel-Crafts reaction for the synthesis of 4-arylpiperidines |
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| Authors: | JS Yadav BV Subba Reddy GGKS Narayana Kumar |
| Institution: | a Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India b Université de Rennes 1, Laboratoire CPM, CNRS UMR 6510, Avenue du Général Leclerc, 35042 Rennes Cedex, France |
| Abstract: | Aldehyde, homoallylic amine and arene undergo smooth cyclization in the presence of BF3·OEt2 to afford 4-arylpiperidines in good yields and with high trans-selectivity. This is the first report on the preparation of 4-arylpiperidines via aza-Prins-Friedel-Crafts reaction. |
| Keywords: | Aza-Prins-Friedel-Crafts reaction Arenes Homoallylic amines 4-Arylpiperidines |
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