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Steroid and cembranoids from the Dongsha atoll soft coral Lobophytum sarcophytoides |
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| Authors: | Yi Lu Zhi-Hong Wen Ping-Jyun Sung Chi-Hsin Hsu Michael Y Chiang Jyh-Horng Sheu |
| Institution: | a Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan b Taiwan Coral Research Center, National Museum of Marine Biology & Aquarium, Checheng, Pingtung 944, Taiwan c Graduate Institute of Marine Biotechnology, National Dong Hwa University, Checheng, Pingtung 944, Taiwan d National Research Institute of Chinese Medicine, Taipei 112, Taiwan e Department of Chemistry, National Sun Yat-sen University, Kaohsiung 804, Taiwan f Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan g Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan |
| Abstract: | A novel sterol, sarcophytosterol (1), and four new cembranoids, sarcophytolins A-D (2-5), have been isolated from the soft coral Lobophytum sarcophytoides along with four known metabolites 6-9. The relative structures of new metabolites were elucidated on the basis of extensive spectroscopic analyses and X-ray diffraction analysis of 1, and the absolute configurations of 1 and 5 were determined by Mosher’s method and CD spectrum, respectively. Compound 1 is a steroid possessing an unusual (20R,23R,24R)-23,24-dimethyl-20-hydroxy side chain. Compounds 3, 6, 8, and 9 were shown to exhibit cytotoxicity toward a limited panel of cancer cell lines. Furthermore, while 1 could effectively enhance the expression of the pro-inflammatory iNOS protein in LPS-stimulated RAW264.7 macrophage cells, compounds 2, 3, 5-7 and 9 were found to effectively inhibit the accumulation of the pro-inflammatory of iNOS. |
| Keywords: | KBQKZBYGDQCBTJ-YQGAQXSRSA-N OKPPSLJDJGOWAJ-UWVYSTBFSA-N IRLJYXHINXXWKC-GHZBUWTKSA-N HBXZGJYKFRYIFQ-NBGGPTHLSA-N YQXSXPBPDWRFHK-LXIPXPQRSA-N |
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