Tragoponol, a dimeric dihydroisocoumarin from Tragopogon porrifolius L. |
| |
Authors: | Christian Zidorn Bent O. Petersen Ernst P. Ellmerer |
| |
Affiliation: | a Institut für Pharmazie der Universität Innsbruck, Abteilung Pharmakognosie, Josef-Moeller-Haus, Innrain 52, A-6020 Innsbruck, Austria b Carlsberg Laboratory, Gamle Carlsberg Vej 10, DK-2500 Valby, Denmark c Institut für Organische Chemie der Universität Innsbruck, Innrain 52a, A-6020 Innsbruck, Austria |
| |
Abstract: | A phytochemical re-investigation of Tragopogon porrifolius L. (Asteraceae) yielded (7S,15S)-2,4,12-trihydroxy-7-(4-hydroxyphenyl)-10-methoxy-15-(4-methoxyphenyl)-7,8,15,16-tetrahydrodibenzo[c,i][1,7]dioxacyclododecine-5,13-dione, named tragoponol, a dimeric dihydroisocoumarin.The compound, which represents the first of its kind, is comprised of the open-chained forms of two different mono-methoxylated dihydroisocoumarin moieties, scorzocreticin and hongkongenin, which are connected via two ester bonds to form a macrolide with two lactone moieties featuring a 12-membered ring. The structure of the nearly symmetrical compound was established by HR mass spectrometry, CD measurements, and extensive 1D and 2D NMR experiments. |
| |
Keywords: | Tragopogon Subtribe Scorzonerinae Tribe Cichorieae Asteraceae Natural products Phenolics |
本文献已被 ScienceDirect 等数据库收录! |
|